Routine measures and alzheimers disease biomarkers in CSF as potential prognostic indicators in diagnostically unresolved patients referred for dementiae evaluation
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منابع مشابه
Are CSF Biomarkers Useful as Prognostic Indicators in Diagnostically Unresolved Cognitively Impaired Patients in a Normal Clinical Setting
BACKGROUND Despite an extensive evaluation program, patients may remain diagnostically unresolved with regard to the etiology of their cognitive dysfunction. Cerebrospinal fluid neuroinflammation and Alzheimer disease (AD) biomarkers may act as indicators of neurodegenerative disorders in diagnostically unresolved patients. METHODS Data on 348 patients were retrospectively evaluated. All part...
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15 صفحه اولTransmembrane Amyloid-Related Proteins in CSF as Potential Biomarkers for Alzheimer’s Disease
In the continuing search for new cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD), reasonable candidates are the secretase enzymes involved in the processing of the amyloid precursor protein (APP), as well as the large proteolytic cleavage fragments sAPPα and sAPPβ. The enzymatic activities of some of these secretases, such as BACE1 and TACE, have been investigated as potential...
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ژورنال
عنوان ژورنال: Journal of the Neurological Sciences
سال: 2015
ISSN: 0022-510X
DOI: 10.1016/j.jns.2015.08.440